Molecular aspects of sickle cell hemoglobin
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Molecular aspects of sickle cell hemoglobin clinical applications. by

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Published by Thomas in Springfield, Ill .
Written in English


  • Sickle cell anemia.

Book details:

Edition Notes

Includes bibliographical references.

StatementEdited by Robert M. Nalbandian. With a foreword by Linus Pauling.
SeriesAmerican lecture series, publication no. 818. A monograph in the Bannerstone division of American lectures in hematology
ContributionsNalbandian, Robert M., 1922-
LC ClassificationsRC641.7.H4 M6
The Physical Object
Paginationxvii, 199 p.
Number of Pages199
ID Numbers
Open LibraryOL4769701M
LC Control Number78157292

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on human hemoglobin variants, and treats the patho- physiology and clinical aspects of sickle-cell anemia, he- moglobin oxidation, and carboxyhemoglobin. This book is rich in the wonderful and important insights that hemoglobin has provided. For example, the authors. Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of . Dec 01,  · The first chapter of this book does, indeed, review the molecular aberrations of sickle hemoglobin. The ingenious hypothesis of molecular stacking of hemoglobin S is ably reviewed by Murayama, who originally proposed this concept. "Molecular aspects" also are reviewed in the beginning of the second Virgil F. Fairbanks. Quantitative disorders of hemoglobin synthesis: Production of structurally normal globin chains, but in decreased amounts (thalassemia syndrome). Qualitative disorders of hemoglobin structure: Production of structurally abnormal globulin chains such as hemoglobin S, C, O, or E. Sickle cell syndrome is the most common example of such disease.

This book is the first attempt to summarize all that we know about the historical and cultural roots of sickle cell anemia and the molecular details of how it attacks humans. The discovery of the molecular basis of sickle cell disease is a riveting story that encapsulates many of the major events in the history of molecular biology. The book offers a synthesis of basic science describing genetic, molecular, metabolic, and rheologic aspects of sickle cell disease. Clinical aspects, including diagnosis and treatment, and psychosocial aspects, covering the interaction of the patient with sickle cell disease with society, are also Vipul Mankad. Disorders of Hemoglobin is the first comprehensive reference on the genetic and acquired disorders of hemoglobin in over a decade. It stands as the definitive work on the genetics, pathophysiology, and clinical management of this wide range of disorders. Drs. Steinberg, Forget, Higgs, and Nagel have gathered the absolute world authorities on the science and clinical management of thalassemias 4/5(2). Nov 15,  · This book is welcomed because it brings under one cover the numerous recent contributions of Dr. Nalbandian and his associates relating to sickle cell theme of the book is that the pathogenesis, diagnosis, and treatment have a molecular basis, that urea is Author: L. W. Diggs.

Sickle cell disease (SCD) is a structural and monogenetic genetic disorder due to a mutation that occurs in the globin β-chain, resulting in the formation of hemoglobin S (Hb S), a protein composed of two normal, and two β-type mutant Karen Cordovil. Sickle cell hemoglobin (HbS) is caused by a mutation that replaces glutamic acid at residue 6 in β-globin with valine (β6 Glu → Val). This amino acid substitution leads to the formation of linear polymers of deoxygenated HbS. Removal of O 2 from HbS in the tissues exposes a complementary site that is also on the surface. The valine residue on the surface of HbS binds to the complementary. understanding sickle cell disease Download understanding sickle cell disease or read online books in PDF, EPUB, Tuebl, and Mobi Format. Click Download or Read Online button to get understanding sickle cell disease book now. This site is like a library, Use search box in the widget to get ebook that you want. Sickle cell disease (SCD) is a group of blood disorders typically inherited from a person's parents. The most common type is known as sickle cell anaemia (SCA). It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blood cells. This leads to a rigid, sickle-like shape under certain circumstances. Problems in sickle cell disease typically begin around 5 to 6 Symptoms: Attacks of pain, anemia, swelling in .